Construct pharmacogenomics (PGx) polygenic risk score (PRS) with PRS-PGx-Unadj (unadjusted), PRS-PGx-CT (clumping and thresholding), PRS-PGx-L, -GL, -SGL (penalized regression), PRS-PGx-Bayes (Bayesian regression). Package is based on ''Pharmacogenomics Polyenic Risk Score for Drug Response Prediction Using PRS-PGx Methods'' by Zhai, S., Zhang, H., Mehrotra, D.V., and Shen, J., 2021 (submitted).

Tests periodicity in short time series using response surface regression.

Intended for larger-than-memory tabular data, 'prt' objects provide an interface to read row and/or column subsets into memory as data.table objects. Data queries, constructed as 'R' expressions, are evaluated using the non-standard evaluation framework provided by 'rlang' and file-backing is powered by the fast and efficient 'fst' package.

Probabilistic Regression Trees (PRTree). Functions for fitting and predicting PRTree models with some adaptations to handle missing values. The main calculations are performed in 'FORTRAN', resulting in highly efficient algorithms.
	This package's implementation is based on the PRTree methodology described in Alkhoury, S.; Devijver, E.; Clausel, M.; Tami, M.; Gaussier, E.; Oppenheim, G. (2020) - "Smooth And Consistent Probabilistic Regression Trees" <https://proceedings.neurips.cc/paper_files/paper/2020/file/8289889263db4a40463e3f358bb7c7a1-Paper.pdf>.

Compute bending energies, principal warps, partial warp scores, and the non-affine component of shape variation for 2D landmark configurations, as well as Mardia-Dryden distributions and self-similar distributions of landmarks, as described in Mitteroecker et al. (2020) <doi:10.1093/sysbio/syaa007>. Working examples to decompose shape variation into small-scale and large-scale components, and to decompose the total shape variation into outline and residual shape components are provided. Two landmark datasets are provided, that quantify skull morphology in humans and papionin primates, respectively from Mitteroecker et al. (2020) <doi:10.5061/dryad.j6q573n8s> and Grunstra et al. (2020) <doi:10.5061/dryad.zkh189373>.