Performs a Necessary Condition Analysis (NCA). (Dul, J. 2016. Necessary Condition Analysis (NCA). ''Logic and Methodology of 'Necessary but not Sufficient' causality." Organizational Research Methods 19(1), 10-52) <doi:10.1177/1094428115584005>.
  NCA identifies necessary (but not sufficient) conditions in datasets, where x causes (e.g. precedes) y. Instead of drawing a regression line ''through the middle of the data'' in an xy-plot, NCA draws the ceiling line. The ceiling line y = f(x) separates the area with observations from the area without observations.
  (Nearly) all observations are below the ceiling line: y <= f(x). The empty zone is in the upper left hand corner of the xy-plot (with the convention that the x-axis is ''horizontal'' and the y-axis is ''vertical'' and that values increase ''upwards'' and ''to the right''). The ceiling line is a (piecewise) linear non-decreasing line: a linear step function or a straight line. It indicates which level of x (e.g. an effort or input) is necessary but not sufficient for a (desired) level of y (e.g. good performance or output). A quick start guide for using this package can be found here: <https://repub.eur.nl/pub/78323/> or <https://papers.ssrn.com/sol3/papers.cfm?abstract_id=2624981>.

A flexible tool that can perform
    (i) traditional non-compartmental analysis (NCA) and
    (ii) Simulation-based posterior predictive checks for population
    pharmacokinetic (PK) and/or pharmacodynamic (PKPD) models using NCA metrics.

Conduct a noncompartmental analysis with industrial strength.
             Some features are
             1) CDISC SDTM terms
             2) Automatic or manual slope selection
             3) Supporting both 'linear-up linear-down' and 'linear-up log-down' method
             4) Interval(partial) AUCs with 'linear' or 'log' interpolation method
             5) Produce pdf, rtf, text report files.
             * Reference: Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016. (ISBN:9198299107).