Functions to compute compositional turnover using zeta-diversity,
    the number of species shared by multiple assemblages. The package includes
    functions to compute zeta-diversity for a specific number of
    assemblages and to compute zeta-diversity for a range of numbers of
    assemblages. It also includes functions to explain how zeta-diversity
    varies with distance and with differences in environmental variables
    between assemblages, using generalised linear models, linear models
    with negative constraints, generalised additive models,shape
    constrained additive models, and I-splines.

The advent of genomic technologies has enabled the generation of two-dimensional or even multi-dimensional high-throughput data, e.g., monitoring multiple changes in gene expression in genome-wide siRNA screens across many different cell types (E Robert McDonald 3rd (2017) <doi: 10.1016/j.cell.2017.07.005> and Tsherniak A (2017) <doi: 10.1016/j.cell.2017.06.010>) or single cell transcriptomics under different experimental conditions. We found that simple computational methods based on a single statistical criterion is no longer adequate for analyzing such multi-dimensional data. We herein introduce 'ZetaSuite', a statistical package initially designed to score hits from two-dimensional RNAi screens.We also illustrate a unique utility of 'ZetaSuite' in analyzing single cell transcriptomics to differentiate rare cells from damaged ones (Vento-Tormo R (2018) <doi: 10.1038/s41586-018-0698-6>). In 'ZetaSuite', we  have the following steps: QC of input datasets, normalization using Z-transformation, Zeta score calculation and hits selection based on defined Screen Strength.

Performs Zoom-Focus Algorithm (ZFA) to optimize testing regions for rare variant association tests in exome sequencing data.

Improve the usage of model fitting functions within a piped
    work flow.

A two-part zero-inflated Beta regression model with random 
    effects (ZIBR) for testing the association between microbial abundance 
    and clinical covariates for longitudinal microbiome data. Eric Z. Chen 
    and Hongzhe Li (2016) <doi:10.1093/bioinformatics/btw308>.