Takes formulas including random-effects components (formatted as in 'lme4', 'glmmTMB', etc.) and processes them. Includes various helper functions.

An R package for estimating conditional multivariate reference regions. 
    The reference region is non parametrically estimated using a kernel density estimator.
    Covariates effects on the multivariate response means vector and variance-covariance
    matrix, thus on the region shape, are estimated by flexible additive predictors. 
    Continuous covariates non linear effects might be estimated using penalized splines smoothers.
    Confidence intervals for the covariates estimated effects might be derived from
    bootstrap resampling. Kernel density bandwidth can be estimated with different methods, including
    a method that optimize the region coverage. Numerical, and graphical, summaries
    can be obtained by the user in order to evaluate reference region performance with real data.
    Full mathematical details can be found in <doi:10.1002/sim.9163> and <doi:10.1007/s00477-020-01901-1>.

Connects dataframes/tables with a remote data source. Raw data downloaded
  from the data source can be further processed and transformed using data preparation 
  code that is also baked into the dataframe/table. Refreshable dataframes can 
  be shared easily (e.g. as R data files). Their users do not need to care about
  the inner workings of the data update mechanisms.

Fetches NCBI data (RefSeq <https://www.ncbi.nlm.nih.gov/refseq/> database) and provides an environment to  
    extract information at the level of gene, mRNA or protein accessions.

Provides subsets with reference semantics, i.e. subsets
    which automatically reflect changes in the original object, and which
    optionally update the original object when they are changed.

Access the 'Refuge' API, a web-application for locating trans and 
    intersex-friendly restrooms, including unisex and accessible restrooms. 
    Includes data on the location of restrooms, along with directions, 
    comments, user ratings and amenities. Coverage is global, but data is 
    most comprehensive in the United States.
    See <https://www.refugerestrooms.org/api/docs/> for full API documentation.