Fit linear models based on periodic splines, moderate model
  coefficients using multivariate adaptive shrinkage, then compute properties of
  the moderated curves.

Functions that (1) find the minimum/maximum of a linear or quadratic function:
  min or max (f(x)), where f(x) = ||Ax-b||^2 or f(x) = sum(a_i*x_i)
  subject to equality constraints Ex=f and/or inequality constraints Gx>=h,
  (2) sample an underdetermined- or overdetermined system Ex=f subject to Gx>=h, and if applicable Ax~=b,      
  (3) solve a linear system Ax=B for the unknown x. It includes banded and tridiagonal linear systems.

Evaluates whether the relationship between two vectors is linear or nonlinear. Performs a test to determine how well a linear model fits the data compared to higher order polynomial models. Jhang et al. (2004) <doi:10.1043/1543-2165(2004)128%3C44:EOLITC%3E2.0.CO;2>.

Short for 'linear binning', the linbin package provides functions
    for manipulating, binning, and plotting linearly referenced data. Although
    developed for data collected on river networks, it can be used with any interval
    or point data referenced to a 1-dimensional coordinate system. Flexible bin
    generation and batch processing makes it easy to compute and visualize variables
    at multiple scales, useful for identifying patterns within and between variables
    and investigating the influence of scale of observation on data interpretation.

Estimate and confidence/credible intervals for an unknown
    regressor x0 given an observed y0.

Perform two linear combination methods for biomarkers: (1) Empirical performance optimization for specificity (or sensitivity) at a controlled sensitivity (or specificity) level of Huang and Sanda (2022) <doi:10.1214/22-aos2210>, and (2) weighted maximum score estimator with empirical minimization of averaged false positive rate and false negative rate. Both adopt the algorithms of Huang and Sanda (2022) <doi:10.1214/22-aos2210>. 'MOSEK' solver is used and needs to be installed; an academic license for 'MOSEK' is free.