Model fitting, optimal model selection and calculation of various features that are essential in the analysis of quantitative real-time polymerase chain reaction (qPCR).

Computes normalized cycle threshold (Ct) values (delta Ct) from raw quantitative polymerase 
    chain reaction (qPCR) Ct values and conducts test of significance using t.test(). Plots expression 
    values based from log2(2^(-1*delta delta Ct)) across groups per gene of interest. Methods for calculation
    of delta delta Ct and relative expression (2^(-1*delta delta Ct)) values are described in: 
    Livak & Schmittgen, (2001) <doi:10.1006/meth.2001.1262>.

Content-preserving transformations transformations of PDF files such 
    as split, combine, and compress. This package interfaces directly to the 'qpdf' 
    C++ API and does not require any command line utilities. Note that 'qpdf' does
    not read actual content from PDF files: to extract text and data you need the
    'pdftools' package.

Efficiently solve quadratic problems with linear inequality, equality and box constraints. The method used is outlined in D. Goldfarb, and A. Idnani (1983) <doi:10.1007/BF02591962>.

Computes noncompartmental pharmacokinetic parameters
 for drug concentration profiles.  For each profile, data
 imputations and adjustments are made as necessary and
 basic parameters are estimated. Supports single dose, multi-dose,
 and multi-subject data.  Supports steady-state calculations
 and various routes of drug administration. See ?qpNCA and vignettes.
 Methodology follows Rowland and Tozer (2011, ISBN:978-0-683-07404-8), 
 Gabrielsson and Weiner (1997, ISBN:978-91-9765-100-4), and
 Gibaldi and Perrier (1982, ISBN:978-0824710422).

A system to implement the Q-Q boxplot.  It is implemented as an
    extension to 'ggplot2'.  The Q-Q boxplot is an amalgam of the boxplot and the
    Q-Q plot and allows the user to rapidly examine summary statistics and tail
    behavior for multiple distributions in the same pane.  As an extension of
    the 'ggplot2' implementation of the boxplot, possible modifications to the 
    boxplot extend to the Q-Q boxplot.