DNA methylation is essential for human, and environment can change the DNA methylation
    and affect body status. Epigenome-Wide Mediation Analysis Study (EMAS) can find
    potential mediator CpG sites between exposure (x) and outcome (y) in epigenome-wide.
    For more information on the methods we used, please see the following references:
    Tingley, D. (2014) <doi:10.18637/jss.v059.i05>,
    Turner, S. D. (2018) <doi:10.21105/joss.00731>,
    Rosseel, D. (2012) <doi:10.18637/jss.v048.i02>.

A light, simple tool for sending emails with minimal dependencies.

Variable selection methods have been extensively developed for analyzing high-dimensional omics data within both the frequentist and Bayesian frameworks. This package implemented the spike-and-slab quantile LASSO which has been developed along the line of Bayesian hierarchical model but deeply rooted in the frequentist regularization methods by utilizing the Expectation–Maximization (EM) algorithm. Therefore, the proposed method borrows strength from both the frequentist and Bayesian frameworks while overcoming their respective limitations. The spike-and-slab quantile LASSO can handle data irregularity in terms of skewness and outliers in the disease trait, compared to its nonrobust alternative, the spike-and-slab LASSO, which has also been implemented in the package. The core module of this package is developed in 'C++'.

Unsupervised, multivariate, binary clustering for meaningful annotation of data, taking into account the uncertainty in the data. A specific constructor for trajectory analysis in movement ecology yields behavioural annotation of trajectories based on estimated local measures of velocity and turning angle, eventually with solar position covariate as a daytime indicator, ("Expectation-Maximization Binary Clustering for Behavioural Annotation").

Predictors can be converted to one or more numeric
    representations using a variety of methods. Effect encodings using
    simple generalized linear models <arXiv:1611.09477> or nonlinear
    models <arXiv:1604.06737> can be used.  There are also functions for
    dimension reduction and other approaches.