Implements several extensions of the elastic net regularization
    scheme. These extensions include individual feature penalties for the L1 term,
    feature-feature penalties for the L2 term, as well as translation coefficients
    for the latter.

Provides functions to calculate the best linear unbiased prediction of genotype-by-environment metrics: ecovalence, environmental variance, Finlay and Wilkinson regression and Lin and Binns superiority measure, based on a multi-environment genomic prediction model.

Fits a multivariate linear mixed effects model that uses a polygenic term, after Zhou & Stephens (2014) (<https://www.nature.com/articles/nmeth.2848>). Of particular interest is the estimation of variance components with restricted maximum likelihood (REML) methods. Genome-wide efficient mixed-model association (GEMMA), as implemented in the package 'gemma2', uses an expectation-maximization algorithm for variance components inference for use in quantitative trait locus studies.

Simulate and analyze multistate models with general hazard
    functions. gems provides functionality for the preparation of hazard functions
    and parameters, simulation from a general multistate model and predicting future
    events. The multistate model is not required to be a Markov model and may take
    the history of previous events into account. In the basic version, it allows
    to simulate from transition-specific hazard function, whose parameters are
    multivariable normally distributed.

Network meta-analyses (mixed treatment comparisons) in the Bayesian
    framework using JAGS. Includes methods to assess heterogeneity and
    inconsistency, and a number of standard visualizations.
    van Valkenhoef et al. (2012) <doi:10.1002/jrsm.1054>;
    van Valkenhoef et al. (2015) <doi:10.1002/jrsm.1167>.

One can find single-stage and two-stage designs for a phase II 
    single-arm study with either efficacy or safety/toxicity endpoints as described in Kim and Wong (2019) <doi:10.29220/CSAM.2019.26.2.163>.