Two Phase I designs are implemented in the package: the classical 3+3 and the Continual Reassessment Method (<doi:10.2307/2531628>). Simulations tools are also available to estimate the operating characteristics of the methods with several user-dependent options.

Complete work flow for the analysis of pharmacokinetic pharmacodynamic (PKPD), physiologically-based pharmacokinetic (PBPK) and systems pharmacology models including: creation of ordinary differential equation-based models, pooled parameter estimation, individual/population based simulations, rule-based simulations for clinical trial design and modeling assays, deployment with a customizable 'Shiny' app, and non-compartmental analysis. System-specific analysis templates can be generated and each element includes integrated reporting with 'PowerPoint' and 'Word'.

Provides a set of functions that can be used to obtain better predictive performance on cost-sensitive and cost/benefits tasks (for both regression and classification). This includes re-sampling approaches that modify the original data set biasing it towards the user preferences.

Fit Bayesian hierarchical models of animal abundance and occurrence
    via the 'rstan' package, the R interface to the 'Stan' C++ library.
    Supported models include single-season occupancy, dynamic occupancy, and
    N-mixture abundance models. Covariates on model parameters are specified
    using a formula-based interface similar to package 'unmarked', while also
    allowing for estimation of random slope and intercept terms. References:
    Carpenter et al. (2017) <doi:10.18637/jss.v076.i01>;
    Fiske and Chandler (2011) <doi:10.18637/jss.v043.i10>.

Calculates the Urban Centrality Index (UCI) as in Pereira et al., 
             (2013) <doi:10.1111/gean.12002>. The UCI measures the 
             extent to which the spatial organization of a city or region varies 
             from extreme polycentric to extreme monocentric in a continuous 
             scale from 0 to 1. Values closer to 0 indicate more polycentric patterns
             and values closer to 1 indicate a more monocentric urban form.