It provides functions to generate operating characteristics and to calculate Sequential Conditional Probability Ratio Tests(SCPRT) efficacy and futility boundary values along with sample/event size of Multi-Arm Multi-Stage(MAMS) trials for different outcomes. The package is based on Jianrong Wu, Yimei Li, Liang Zhu (2023) <doi:10.1002/sim.9682>, Jianrong Wu, Yimei Li (2023) "Group Sequential Multi-Arm Multi-Stage Survival Trial Design with Treatment Selection"(Manuscript accepted for publication) and Jianrong Wu, Yimei Li, Shengping Yang (2023) "Group Sequential Multi-Arm Multi-Stage Trial Design with Ordinal Endpoints"(In preparation).

Tools rewritten in C for various smoothing tasks

Estimating trait heritability and handling overfitting. This package includes a collection of functions for (1) estimating genetic variance-covariances and calculate trait heritability; and (2) handling overfitting by calculating the variance components and the heritability through cross validation.

Provides automated downloading, parsing, cleaning, unit conversion
    and formatting of Global Surface Summary of the Day ('GSOD') weather data
    from the from the USA National Centers for Environmental Information
    ('NCEI').  Units are converted from from United States Customary System
    ('USCS') units to International System of Units ('SI').  Stations may be
    individually checked for number of missing days defined by the user, where
    stations with too many missing observations are omitted.  Only stations with
    valid reported latitude and longitude values are permitted in the final
    data.  Additional useful elements, saturation vapour pressure ('es'), actual
    vapour pressure ('ea') and relative humidity ('RH') are calculated from the
    original data using the improved August-Roche-Magnus approximation (Alduchov
    & Eskridge 1996) and included in the final data set.  The resulting metadata
    include station identification information, country, state, latitude,
    longitude, elevation, weather observations and associated flags.  For
    information on the 'GSOD' data from 'NCEI', please see the 'GSOD'
    'readme.txt' file available from,
    <https://www1.ncdc.noaa.gov/pub/data/gsod/readme.txt>.