********************************************************************************
*                          pk.turnover.emax3.mlxtran                           *
*                          May 13, 2022 at 17:51:00                            *
*                          Monolix version : 2020R1                            *
********************************************************************************


ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------    se_lin    rse(%)
ktr_pop    :                          1.24     0.222      17.9
ka_pop     :                          1.01     0.116      11.6
cl_pop     :                         0.135   0.00696      5.17
v_pop      :                          7.73     0.338      4.38
emax_pop   :                         0.989   0.00588     0.595
ec50_pop   :                          1.08    0.0963       8.9
kout_pop   :                         0.053   0.00138       2.6
e0_pop     :                          96.7       1.1      1.14

Standard Deviation of the Random Effects -
omega_ktr  :                         0.731     0.138      18.9
omega_ka   :                         0.461    0.0907      19.7
omega_cl   :                         0.279    0.0379      13.6
omega_v    :                         0.223    0.0334        15
omega_emax :                          0.38      0.67       176
omega_ec50 :                         0.454    0.0643      14.2
omega_kout :                        0.0786    0.0293      37.2
omega_e0   :                        0.0508    0.0101      19.8

Error Model Parameters -------------------
pkadd__err :                         0.533    0.0625      11.7
prop__err  :                        0.0986    0.0115      11.7
pdadd__err :                          3.79     0.252      6.64

Elapsed time (seconds) :      95
CPU time     (seconds) :  1.6e+2

 _______________________________________________________________________________



ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________


Estimation of the individual parameters by Conditional Distribution ------------
             min        Q1    median        Q3       max
ktr  :     0.361      1.42      1.64      1.83      3.35
ka   :     0.424      1.08      1.14      1.25      2.08
cl   :    0.0763     0.108      0.13     0.163     0.272
v    :      5.05      6.61      8.08      8.95      11.7
emax :     0.986     0.987     0.988     0.989     0.989
ec50 :     0.495      0.78      1.09      1.51      2.29
kout :    0.0481    0.0511     0.053    0.0549    0.0587
e0   :      88.8      92.8      98.4      99.7       104

Elapsed time (seconds) :      16
CPU time     (seconds) :      27

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Estimation of the individual parameters by Conditional Mode --------------------
             min        Q1    median        Q3       max
ktr  :     0.347      1.11      1.28      1.39      2.61
ka   :     0.414     0.992      1.03      1.11      1.76
cl   :    0.0761     0.109     0.131     0.163     0.269
v    :      5.04      6.64         8      8.78      11.7
emax :     0.988     0.989     0.989     0.989     0.991
ec50 :     0.482     0.767      1.09      1.52      2.29
kout :    0.0477    0.0513    0.0525    0.0548    0.0584
e0   :        89      93.4      98.6      99.5       104

Elapsed time (seconds) :     1.7
CPU time     (seconds) :       3

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 _______________________________________________________________________________



ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Linearization -------------------

Correlation Matrix :
   ktr_pop         1
    ka_pop -0.016803         1
    cl_pop -0.021412 -0.018683         1
     v_pop-0.0030511  0.010181  0.027893         1
  emax_pop -0.021678  0.011874  0.012068-0.0068716         1
  ec50_pop-0.0003873  0.020658 -0.039323  0.025942   0.22998         1
  kout_pop -0.017286-0.0045614 -0.042775   0.10162  -0.35709   0.01748         1
    e0_pop 0.0050714-0.00035984 -0.010292  0.014564   0.00983  -0.05098   0.11932         1
 omega_ktr         0         0         0         0         0         0         0         0         1
  omega_ka         0         0         0         0         0         0         0         0  -0.10531         1
  omega_cl         0         0         0         0         0         0         0         0-0.00052773-0.00052597         1
   omega_v         0         0         0         0         0         0         0         0-0.00013385-0.00038152 -0.014624         1
omega_emax         0         0         0         0         0         0         0         0-0.00078656 -0.003227-0.000155290.00028314         1
omega_ec50         0         0         0         0         0         0         0         0 1.4757e-5-0.0029707-0.0017422-9.1688e-6 -0.025114         1
omega_kout         0         0         0         0         0         0         0         0-0.0020677 0.0015084-0.00077646 -0.011245 -0.026589 -0.011634         1
  omega_e0         0         0         0         0         0         0         0         0-0.000103980.00064038 0.00033580.00065343 0.0088111-0.0015615  0.025628         1
pkadd__err         0         0         0         0         0         0         0         00.000234610.00040077 -0.017589 0.0010744-0.0047821 -0.010666 -0.010711 0.0030129         1
 prop__err         0         0         0         0         0         0         0         0   -0.0158  -0.01106-0.00053756 -0.044857-0.0015218 0.0015448-0.0022099-0.00024214   -0.5809         1
pdadd__err         0         0         0         0         0         0         0         0-0.0013211 -0.011816 -0.002878 -0.003159 -0.062959 -0.024685  -0.26258  -0.16977 -0.025776 0.0027481         1

                               min       max   max/min
Eigen values           :      0.42       1.6       3.8

Elapsed time (seconds) :   0.087
CPU time     (seconds) :       0

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 _______________________________________________________________________________



ESTIMATION OF THE LOG-LIKELIHOOD _______________________________________________

                                                           (lin)
-2 x log-likelihood                       (OFV) :        2411.69
Akaike Information Criteria               (AIC) :        2449.69
Corrected Bayesian Information Criteria  (BICc) :        2507.40
Bayesian Information Criteria             (BIC) :        2477.54

Elapsed time                          (seconds) :           0.00
CPU time                              (seconds) :           0.00

 _______________________________________________________________________________

DATASET INFORMATION
Number of individuals: 32
Number of observations (obsid 1): 251
Number of observations (obsid 2): 232
Number of doses: 32

